Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues.
نویسندگان
چکیده
Feeding 5-hydroxy and 5-fluorotryptophan to a Streptomyces coelicolor Trp-auxotrophic strain WH101 results in the production of a number of new calcium-dependent antibiotics (CDAs) possessing modified Trp residues. It is anticipated that this method could be used to modulate the biological properties of Trp-containing nonribosomal peptide natural products, or to generate analogues with useful fluorescent properties for studying biological mechanisms of action.
منابع مشابه
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 6 6 شماره
صفحات -
تاریخ انتشار 2008